Poster presentation for ICCT conference in Mikulov. The most common way to produce renewable diesel is transesterification of triglycerides to produce FAME (Fatty acid methyl ester). However, advanced biofuels can be produced by co-processing of these triglycerides with middle distillates and some other petroleum fractions in refinery hydrotreating units. The main advantages are better quality and stability in comparison with FAME. The co-processing involves the sulphur and nitrogen removal from middle distillates, as well as the oxygen from the triglyceride component. The hydrotreatment of vegetable oil produces HVO (Hydrotreated Vegetable oil), containing mainly linear hydrocarbons (nC15-18), light gases, (C3H8, CH4 and COx) and water. The conventional catalysts for HDS (hydrodesulphurization) in refineries are sulphided catalysts with Mo or W as active metals, and Ni or Co as promotors. The most common catalyst support is Al2O3. To avoid decrease of HDS efficiency and reactor overheating during co-processing, only limited concentration of vegetable oil can be used. Sulphur free catalysts as molybdenum carbide or nitride represent a promising alternative to resolve the problem of the catalyst HDS activity in the presence of vegetable oils.